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  Indian J Med Microbiol
 

Figure 2: Mechanism of mitophagy mediated by pink1-parkin pathway 1 Pink1 is constitutively degraded in healthy mitochondria. 2 Accumulation of Pink1 at the outer membrane and recruits PARKIN and Mfn2 acts as a receptor for PARKIN on mitochondria 3 PARKIN ubiquitinates, p62, an OMM protein, which binds with LC3 (adapter protein), PARKIN, subsequently induces autophagy. 4-6 Mitochondria is subsequently degraded by the autophagic process

Figure 2: Mechanism of mitophagy mediated by pink1-parkin pathway 1 Pink1 is constitutively degraded in healthy mitochondria. 2 Accumulation of Pink1 at the outer membrane and recruits PARKIN and Mfn2 acts as a receptor for PARKIN on mitochondria 3 PARKIN ubiquitinates, p62, an OMM protein, which binds with LC3 (adapter protein), PARKIN, subsequently induces autophagy. 4-6 Mitochondria is subsequently degraded by the autophagic process