National Journal of Maxillofacial Surgery

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 6  |  Issue : 2  |  Page : 176--179

Fucose: A biomarker in grading of oral cancer


Satish Kumar1, Mona Saxena2, Kandakurtis Srinivas1, Vinod Kumar Singh2 
1 Department of Oral Medicine, Career Post Graduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India
2 Department of Biochemistry, Career Institute of Medical Sciences and Hospital, Lucknow, Uttar Pradesh, India

Correspondence Address:
Dr. Mona Saxena
Ram Lodge, 417/214, Newazganj, Lucknow - 226 003, Uttar Pradesh
India

Introduction: Early diagnosis of cancer helps a great deal in the management of oral cancer patients. Number of proteinous markers have been employed for this purpose. Majority of them are not specific. Recently conjugated oligosaccharide with proteins and lipids have gained considerable importance in the present postgenomics and postproteomic period in the diagnostic and prognostics of cancer cases. Materials and Methods: In this study, serum fucose levels were estimated in 50 control cases and 75 cases of oral cancer by the method of Dische and Shettles as adopted by Winzler. Results: Serum fucose levels were found to be significantly higher in oral cancer cases (46.63 ± 5.29 mg/dl) as compared to the control cases (7.22 ± 0.26 mg/dl). The stepwise elevated serum fucose levels were found to be correlated with the histopathological grading of oral cancer. Conclusions: Estimation of such fucose conjugated proteins is suggestive to be good biomarkers in the diagnosis of oral cancer cases as well as in assessing the prognosis of such cases.


How to cite this article:
Kumar S, Saxena M, Srinivas K, Singh VK. Fucose: A biomarker in grading of oral cancer.Natl J Maxillofac Surg 2015;6:176-179


How to cite this URL:
Kumar S, Saxena M, Srinivas K, Singh VK. Fucose: A biomarker in grading of oral cancer. Natl J Maxillofac Surg [serial online] 2015 [cited 2022 Oct 4 ];6:176-179
Available from: https://www.njms.in/article.asp?issn=0975-5950;year=2015;volume=6;issue=2;spage=176;epage=179;aulast=Kumar;type=0