Home | About us | Editorial board | Ahead of print | Current issue | Archives | Search | Submit article | Instructions | Subscribe | Advertise | Contact us |  Login 
National Journal of Maxillofacial Surgery
Print this page Email this page Small font sizeDefault font sizeIncrease font size
Users Online: 1702

Table of Contents
Year : 2013  |  Volume : 4  |  Issue : 1  |  Page : 13-18  

Sialoblastoma: A literature review from 1966-2011

1 Dental Section, 320 Filed Hospital, Bhubaneshwar, Odisha, India
2 Institute of Dental Sciences, Bhubaneshwar, Odisha, India
3 Department of Oral and Maxillofacial Pathology, Government Dental College, Trivandrum, India
4 Department of Pedodontics, Government Dental College, Trivandrum, India

Date of Web Publication7-Sep-2013

Correspondence Address:
Kanaram Choudhary
B-8, 201, Sidhivinyaka, Shantividhyanagri, Next to GCC, Mira Road (East), Thane, Maharashtra
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-5950.117821

Rights and Permissions

Sialoblastoma is a rare congenital tumour of the salivary glands arising mainly from the parotid gland. It is usually diagnosed at birth or shortly thereafter with a significant variability in histological appearance and clinical course. In extensive search of PubMed indexed journals, we got 46 cases of "sialobalstoma/embryoma/congenital basal adenoma", with one case was of German literature and three additional cases of adult sialobalstoma. This article has extensively reviewed the clinical, histopathological and immunohistochemical features, Magnetic resonance imaging (MRI) and Computerized Tomography (CT) findings, treatment and prognosis.

Keywords: Congenital basal cell adenoma, embryoma, sialoblastoma

How to cite this article:
Choudhary K, Panda S, Beena V T, Rajeev R, Sivakumar R, Krishanan S. Sialoblastoma: A literature review from 1966-2011. Natl J Maxillofac Surg 2013;4:13-8

How to cite this URL:
Choudhary K, Panda S, Beena V T, Rajeev R, Sivakumar R, Krishanan S. Sialoblastoma: A literature review from 1966-2011. Natl J Maxillofac Surg [serial online] 2013 [cited 2022 Sep 25];4:13-8. Available from: https://www.njms.in/text.asp?2013/4/1/13/117821

   Introduction Top

Tumours that originate in the ductal or secretory epithelial cells of salivary gland are exceedingly rare in children < 2 years of age. [1] A group of tumours has been recognized those usually presents at birth or shortly thereafter, and are composed of basaloid and myoepithelial cells that recapitulate the developing salivary anlage. These tumours have been reported under a variety of names such as congenital basal cell adenoma, basal cell adenoma, basaloid adenocarcinoma, and congenital hybrid basal cell adenoma-adenoid cystic carcinoma, etc. [2] Vawter and Tefft [3] suggested the term embryoma in 1966 for this unique perinatal tumour. Alternatively in 1988, Taylor [4] suggested the term sialoblastoma, because it conveyed both the dysontogenetic character as well as the tumour site within a single name. In extensive PubMed search with keywords "sialoblastoma, embryoma, congenital basal cell adenoma". We have found out total of 46 cases with these key words. Most of reported cases are single case report. In addition three cases of adult sialoblastoma were identified. We have reviewed 40 cases tabulated by Saffari et al. [5] in 2011 [Table 1]. Additional 6 cases we have identified (2010-2011) in literature so all together we reviewed 46 cases of sialoblastoma/embryoma/congenital basal cell adenoma [Table 2]. 3 adult sialoblastoma [6] cases were also identified and reviewed [Table 2].
Table 1: Congenital sialoblastoma/embryoma/basal cell adenoma[5]

Click here to view
Table 2: Cases of paediatric and adult sialoblastoma 2010 - 2011, 2010* adult SB

Click here to view

   Discussion Top


Most tumours have been diagnosed at birth; cases from 34 week of fetus to four year of age have been identified in English language literature. [Table 1] and [Table 2] A Case of 7 year/F reported in German literature. [7] 29 cases (63.03%) were of less than 10 days of age. Male 22, female 23, almost equally affected. In one case sex has not been mentioned. 31 tumour were related to parotid, [3],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21],[22],[23],[24],[25],[26],[27],[28],[29] 11 submandibular, [12],[18],[30],[31],[32],[33],[34],[35],[36] two cheek minor salivary gland, [5],[37] one was in relation with eyelid minor salivary gland [38] and one presented as face and neck mass [39 ] [Table 1] and [Table 2]

Clinical features

Clinically most of babies presented as cheek and submandibular mass. The reported size of tumor ranges from a peanut to a maximum of 15 cm in diameter. [28],[39] At one occasion it was associated with superficial haemorrhage and necrosis. [39] The clinical diagnosis in one of the case was found to be Hemangioma. [37] In two of the reported cases, associated hepatoblstoma with increased level of Alfa-Feto Protein (AFP), [11],[23] was found and another, two cases have associated cutaneous hamartoma [24],[35] and one with congenital nevus has also been reported. [14] Ozdemir et al. [25] reported a case of congenital sialoblastoma presenting with the premature centromere division (PCD) and a high level of AFP, which associations have not previously been reported. After resection of tumour AFP level decrease to normal. Their case was the first sialoblastoma associated with high levels of AFP. The principal site of synthesis of AFP is the fetal liver. In the human fetus, the level of AFP falls with increasing maturation. [40] Elevated values of AFP in the neonatal period have been detected in malignant germ cell neoplasms, massive hepatocellular carcinoma, and hereditary tyrosinemia type I. [41],[42] Siddiqi et al. [11] reported a case of sialoblastoma and hepatoblastoma in a neonate. The liver of the case reported by Ozdemir et al. [25] was examined by ultrasound and magnetic resonance imaging and there was no finding of hepatocellular carcinoma.

MRI and CT findings

Imaging features of sialoblastoma have been documented in a limited number of cases. [11],[14] The CT appearance is of a soft-tissue mass hypodense to the brain and isodense to muscle. Som et al. [14] detected low-intermediate signal intensity and slightly higher intermediate signal intensity on T1-weighted (T1-W) and T2-weighted (T2-W) images, respectively. In a case reported by Yekeler et al. [9] the greater part of the lesion excluding necrotic and haemorrhagic areas was mildly hyper intense on T2-W images, which was lower than that described by Som et al. [14] The finding of mild hyperintensity on T2-W images suggests a high nucleus/cytoplasmic ratio belonging to blastoma and can be predictive for the diagnosis of blastomas. In their case, [14] the cause of intralesional haemorrhage on MRI was unclear. It could have occurred spontaneously into the fragile tumour tissue or have resulted from minor trauma during vaginal delivery.

Histopathological features

The morphology of sialoblastoma is very characteristic with the presence of nests of basaloid cells with a palisading pattern at the periphery and maturation toward the centre. Sialoblastomas may have admixed histologic appearance, ranging from benign hamartomatous lesions with marked similarity to normal fetal salivary gland tissue to highly malignant tumour. [16] Batsakis and colleague [17] proposed histologic criteria for assessment of malignancy in a sialoblastoma, which included "invasion of nerves or vascular spaces and ancillary findings of necrosis and cytological atypia beyond that expected or presumed for an embryonic epithelium. Mitotic figures are variable, 3-4/High Power Field (HPF), and 6-7/10 HPF to 20/10 HPF has been reported in recurrent cases. [13] Areas of necrosis also increased in recurrent cases [13] necrosis with focal calcification in isolated cases [34] and necrosis with total tumour replacement of tumour stroma after chemotherapy. [28] Proliferative index from 3cell/10 HPF to 94 cell/10 HPF has been reported. [13]

Williums et al., [18] studied clinicopathological and immunohistochemical features of seven cases from the files of the Armed Forces Institute of Pathology. According to their study there is a male to female ratio of 4:3 and age ranging from prenatal to six months at the time of discovery. Five lesions originated from the parotid gland; 2 lesions were from the submandibular gland. All lesions presented as nodular to multinodular swellings and ranged in size from 2.0 to 7.0 cm. The principal sign or symptom was rapid growth. Two histologic patterns with differing behaviour predominated: (1) A favourable pattern had semi encapsulation of cytologically benign basaloid tumour cells with intervening stroma; and (2) an unfavourable histology of anaplastic basaloid tumour cells, minimal stroma, and broad pushing to infiltrative periphery. Four and three tumours had favourable and unfavourable growth patterns, respectively. One unfavourable lesion had vascular invasion, and another demonstrated perineural invasion. All three tumours with unfavourable histology recurred. Tumour cells in three cases were immunohistochemically reactive for keratin, S-100, smooth muscle actin, and calponin to varying degrees. All three tumours were reactive for p63. AFP was expressed in two unfavourable tumours. AFP positivity also reported by xx. Ki67 was expressed at 3% in a favourable tumour and 40 and 80% in the two unfavourable lesions. Yasi et al. [5] has reported Ki-67 (30%) in their case. As a prognostic marker, Ki67 immunostaining demonstrated expected findings of a lower proliferative index in the favourable tumour in one case as opposed to significantly higher indices in unfavourable tumours two cases. In the case study by Brandwein et al. [13] Ki67 developed as a significant finding in the course of the recurrences of tumour. The incorporation of Ki67 index with the favourable/unfavourable histologic indicator may be useful for the prognosis of these tumours. So immunohistochemical these tumour express S-100 and vimentin diffusely. Cytokeratin accentuated the ductal structure. [2]

Recurrence and metastasis

10 cases recurred after initial treatment. [3],[4],[16],[26],[28],[29] Most of them recurred within 24 month. Four cases of lung metastasis with two cases have multiple lung metastasis and two cases of cervical lymph node metastasis have been reported. [10],[27],[29] In reported cases no case succumbed to death due to recurrence or metastasis [Table 1] and [Table 2].


Various treatment modalities like surgical excision, chemotherapy, radiotherapy and combination for primaries, recurrent and metastatic cases have been mentioned. One case spontaneously regresses after FNAC till one year than increased in size, treated with superficial parotidectomy and recurred. After metastasis to lung treated with chemotherapy and got complete response. [27] One case treated with 125 I brachytherapy, [28] cured completely [Table 1] and [Table 2].


Only three cases succumbed to death; due to septicaemia, [23] respiratory unsuffeciency [8] and unrelated to sialoblastoma, [18] one in each category. In reported literature maximum of 43 year of disease free survival has been reported. [18] In most of cases functional and aesthetic efficacy has been achieved.


Ozdemir et al. [25] reported a case of congenital sialoblastoma presenting with the PCD and a high level of AFP, which associations have not previously been reported.

Adult sialoblastoma

Essentially, sialoblastoma is a disease of infancy with the oldest case presenting at four and seven year of age in English and German literature respectively [Table 1] and [Table 2]. About one third of pediatric sialoblastoma cases will have a cribriform growth pattern. No adult cases have been reported with a specific diagnosis of sialoblastoma. If even focal cribriforming were present, such cases have undoubtedly been diagnosed as adenoid cystic carcinoma. [6] Such was the circumstance in the three adult tumours presented by Dardic et al. [6] Each case, however, has the primitive histopathology with discrete nests of basaloid tumour cells, associated bilayered ductal structures and the fibromyxoid stroma characteristic for sialoblastoma with its resemblance to fetal salivary gland or salivary gland with arrested development. Sialoblastoma, whether in a child or adult with or without a cribriform growth pattern, appears to have a more favourable prognosis than adenoid cystic carcinoma. Detailed data mentioned in [Table 1] (2010 * 1, 2 and 3).

In adult sialoblastoma cases, cribriform histology needs to be tempered with the overall primitive organization of the basaloid tumor cells, often with associated single or branching ductal structures, enclosed by loose collagenous to myxoid stroma. The latter aspects produce a likeness to developing salivary gland in the fetus and, as a hallmark of sialoblastoma, are an essential diagnostic feature. It is notable that sialoblastomas are generally circumscribed and even partially encapsulated. A cribriform growth pattern does not necessarily imply adenoid cystic carcinoma with its inherently poor long-term prognosis. [6] The synthesis of excess glycosaminoglycans myoepithelial cells-responsible for discrete intercellular spaces or histologic variants associated with this process-is common to a number of salivary gland tumors, including pleomorphic adenoma, myoepithelioma, basal cell adenoma, epithelial-myoepithelial carcinoma, and polymorphous low-grade adenocarcinoma. [43],[44],[45],[46] Ultrastructural studies of some cases of sialoblastoma reveal reduplication of basal lamina, [16],[47] and in one adult example in this report, frank intercellular accumulations of glycosaminoglycans and basal lamina in association with basaloid tumor cells. [48] and basal lamina by neoplastic basal/Sialoblastoma is, therefore, another salivary gland tumor with a potential for a cribriform element.

   Conclusion Top

Sialoblastoma is rare salivary gland tumours, almost all cases have been reported below four year of age in English literature. Recently cases of adult sialoblastoma have been reported. And it has been suggested that cribriform pattern is evident in sialoblastoma. Surgical excision with negative margin is mainstay of treatment, yet in unresectable case brachetherapy has been used successfully. Instead of rapid growth potential prognosis is good; no death has been reported due to metastasis. Existence of adult sialobalstoma needed further clarification with large case series.[50]

   References Top

1.Batsakis JG, Frankenthaler R. Embryoma (sialoblastoma) of salivary glands. Ann Otol Rhinol Laryngol 1992;101:958-60.  Back to cited text no. 1
2.Leon B, John WE, Peter R, David S. Pathology and genetic. WHO Head and Neck Tumor. 5 th ed. Brandwein Gensler. Sialoblastoma. 2005. p. 253.  Back to cited text no. 2
3.Vawter GF, Tefft M. Congenital tumors of the parotid gland. Arch Pathol 1966;82:242-5.  Back to cited text no. 3
4.Taylor GP. Congenital epithelial tumor of the parotid-sialoblastoma. Pediatr Pathol 1988;8:447-52.  Back to cited text no. 4
5.Saffari Y, Blei F, Warren SM, Milla S, Greco MA. Congenital minor salivary gland sialoblastoma: A case report and review of the literature. Fetal Pediatr Pathol 2011;30:32-9.  Back to cited text no. 5
6.Dardick I, Thomas TD, McComb RJ. Sialoblastoma in adults: Distinction from adenoid cystic Carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;109:109-16.  Back to cited text no. 6
7.Seifert G, Donath K. Juvenile pleomorphic parotid adenoma of embryonal structure. Pathologe 1998;19:286-91.  Back to cited text no. 7
8.Tatlidede S, Karsidag S, Ugurlu K, Sadikoglu B, Tanik C, Bas L. Sialoblastoma: A congenital epithelial tumor of the salivary gland. J Pediatr Surg 2006;41:1322-5.  Back to cited text no. 8
9.Yekeler E, Dursun M, Gun F, Kilincaslan H, Ucar A, Genchellac H, et al. Sialoblastoma: MRI findings. Pediatr Radiol 2004;34:1005-7.  Back to cited text no. 9
10.Huang R, Jaffer S. Imprint cytology of metastatic sialoblastoma. A case report. Acta Cytol 2003;47:1123-6.  Back to cited text no. 10
11.Siddiqi SH, Solomon MP, Haller JO. Sialoblastoma and hepatoblastoma in a neonate. Pediatr Radiol 2000;30:349-51.  Back to cited text no. 11
12.Seifert G, Donath K. The congenital basal cell adenoma of salivary glands. Contribution to the differential diagnosis of congenital salivary gland tumours. Virchows Arch1997;430:311-9.  Back to cited text no. 12
13.Brandwein M, Al-Naeif NS, Manwani D, Som P, Goldfeder L, Rothschild M, et al. Sialoblastoma: Clinicopathological/immunohistochemical study. Am J Surg Pathol 1993;23:324-48.  Back to cited text no. 13
14.Som PM, Brandwein M, Silvers AR Rothschild MA. Sialoblastoma (embryoma): MR findings of a rare pediatric salivary gland tumor. AJNR Am J Neuroradiol 1997;18:847-50.  Back to cited text no. 14
15.Alvarez-Mendoza A, Calderon-Elvir C, Carrasco-Daza D. Diagnostic and therapeutic approach to sialoblastoma: Report of a case. J Pediatr Surg 1999;34:1875-7.  Back to cited text no. 15
16.Hsueh C, Gonzalez-Crussi F. Sialoblastoma: A case report and review of the literature on congenital epithelial tumors of salivary gland origin. Pediatr Pathol 1992;12:205-14.  Back to cited text no. 16
17.Batsakis JG, Mackay B, Ryka AF, Seifert RW. Perinatal salivary gland tumours (embryomas). J Laryngo Otol 1988;102;1007-11.  Back to cited text no. 17
18.Williams SB, Ellis GL, Warnock GR. Sialoblastoma: A clinicopathologic and immunohistochemical study of 7 cases. Ann Diagn Pathol 2006;10:320-6.  Back to cited text no. 18
19.Solomon MR, Kaleem Z, Chen CK. Concurrent sialoblastoma (embryoma) of parotid gland and hepatoblastoma (fetal type) arising in a new born: A previously unreported association (abstract). Congress of the International Association of Oral Pathologists (IAOP), York England, July 1994, Abstract P37.  Back to cited text no. 19
20.Casas LA, Gonzalew-Crussi F, Pensler JM. Monomorphic adenoma of the parotid in a premature neonate. Ann Plast Surg 1989;22:47-9.  Back to cited text no. 20
21.Roth A, Michean C. Embryoma (or embryonal tumor) of the parotid gland: Report of two cases. Pediatr Pathol 1986;5:9.  Back to cited text no. 21
22.Canalis RF, Mok MW, Fishman SM, Hemenway WG. Congenital basal cell adenoma of the submandibular gland. Arch Otolaryngol 1980;106:284-6.  Back to cited text no. 22
23.Stones DK, Jansen JC, Griessel D. Sialoblastoma and hepatoblastoma in a new born infant. Pediatr Blood Cancer 2008;52:883-5.  Back to cited text no. 23
24.Scott JX, Krishnan S, Bourne AJ, Williams MP, Agzarian M, Revesz T. Treatment of metastatic sialoblastoma with chemotherapy and surgery. Pediatr Blood Cancer 2008;50:134-7.  Back to cited text no. 24
25.Ozdemir I, Simsek E, Silan F, Demirci F. Congenital sialoblastoma (embryoma) associated with premature centromere division and high level of alpha-fetoprotein. Prenat Diagn 2005;25:687-9.  Back to cited text no. 25
26.Kattoor J, Baisakh MR, Mathew A, Somanathan T, Nayak N, Abraham EK. Sialoblastoma: A rare salivary gland neoplasm. Indian J Cancer 2010;47:219-20.  Back to cited text no. 26
[PUBMED]  Medknow Journal  
27.Prigent M, Teissier N, Peuchmaur M, Maleh-Berges ME, Philippe-Chomette P, Cardin P, et al. Sialoblastoma of salivary glands in children: Chemotherapy should be discussed as an alternative to mutilating surgery. Int J Pediatr Otorhinolaryngol 2010;74:942-5.  Back to cited text no. 27
28.Shan XF, Cai ZG, Zhang JG, Zhang J, Gao Y, Yu GY. Management of sialoblastoma with surgery and brachytherapy. Pediatr Blood Cancer 2010;55:1427-30.  Back to cited text no. 28
29.Farooqi KM, Kessel R, Brandwein-Gensler M, Granowetter L, Manwani D. Sialoblastoma-long-term follow-up and remission for a rare salivary malignancy. Rare Tumors 2011;3:e13.  Back to cited text no. 29
30.Harris MD, McKeevcr P, Rohcrtson JM. Congenital tumours of the salivary gland: A case report and review. Histopathology 1990;17:155-7.  Back to cited text no. 30
31.Vidyadhar M, Amanda C, Thuan Q, Prabhakaran K. Sialoblastoma. J Pediatr Surg 2008;43:e11-3.  Back to cited text no. 31
32.Cristofaro M, Giudice A, Amentea M, Giudice M. Diagnostic and therapeutic approach to sialoblastoma of submandibular gland: A case report. J Oral Maxillofac Surg 2008;66:123-6.  Back to cited text no. 32
33.Verret DJ, Galindo RL, DeFatta RJ, Bauer PW. Sialoblastoma: A rare submandibular gland neoplasm. Ear Nose Throat J 2006;85:440-2.  Back to cited text no. 33
34.Garrido A, Humphrey G, Squire RS, Nishikawa H. Sialoblastoma. Br J Plast Surg 2000;53:697-9.  Back to cited text no. 34
35.Green RS, Tunkel DE, Small D, Westra WH, Argani P. Sialoblastoma: Association with cutaneous hamartom (organoid nevus)? Pediatr Dev Pathol 2000;3:504-5.  Back to cited text no. 35
36.Mostafapour S. Sialoblastoma of the submandibular gland: Report of case and review of the literature. Int J Pediatr Otorhinolaryngol 2000;53;157-61.  Back to cited text no. 36
37.Marucci DD, Lawson K, Harper J, Sebire NJ, Dunaway DJ. Sialoblastoma arising in ectopic salivary gland tissue. J Plas Reconstr Aesthet Surg 2009;62:e241-60.  Back to cited text no. 37
38.Shet T, Ramadwar M, Sharma S, Laskar S, Arora B, Kurkure P. An eyelid sialoblastoma-like tumor with a sarcomatoid myoepithelial component. Pediatr Dev Pathol 2007;10:309-14.  Back to cited text no. 38
39.Saribeyoglu ET, Devecioglu O, Karakas Z, Anak S, Unuvar A, Agaoglu L, et al. How to manage an unresectable or recurrent sialoblastoma. Pediatr Blood Cancer 2010;55:374-6.  Back to cited text no. 39
40.Adinolfi A, Adinolfi M, Lessof. Alpha-feto-protein during development and in disease. J Med Genet 1975;12:138-51.  Back to cited text no. 40
41.Mann JR, Raafat F, Robinson K, Imeson J, Gornall P, Sokal M, et al. The United Kingdom children's cancer study group's second germ cell tumor study: Carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. J Clin Oncol 2000;18:3809-18.  Back to cited text no. 41
42.Pitkanen S, Salo MK, Kuusela P, Holmberg C, Simell O, Heikinheimo M. Serum levels of oncofetal markers CA 125, CA 19-9, and alpha-fetoprotein in children with hereditary tyrosinemia type I. Pediatr Res 1994;35:205-8.  Back to cited text no. 42
43.Dardick I. Color atlas/text of salivary gland tumor pathology. vol. 83. New York: Igaku-Shoin Medical Publishers, Inc; 1996. p. 215.  Back to cited text no. 43
44.Grenco RT, Abendroth CS, Davis AT, Levin RJ, Dardick I. Hybrid tumors or salivary gland tumors sharing a common pathway? Reexamining adenoid cystic and epithelial-myoepithelial carcinomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86:188-95.  Back to cited text no. 44
45.Böör A, Jurkovic I, Kocan P, Jenca A. Collagenous spherulosis in epithelial-myoepithelial carcinoma of the parotid gland: Histological and immunohistochemical study of a case. ORL J Otorhinolaryngol Relat Spec2002;64:148-51.  Back to cited text no. 45
46.Araújo VC, Loducca SV, Sousa SO, Williams DM, Araújo NS. The cribriform features of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma: Cytokeratin and integrin expression. Ann Diagn Pathol 2001;5:330-4.  Back to cited text no. 46
47.Simpson PR, Rutledge JC, Schaefer SD, Anderson RC. Congenital hybrid basal cell adenoma-adenoid cystic carcinoma of the salivary gland. Pediatr Pathol 1986;6:199-208.  Back to cited text no. 47
48.Daley TD, Dardick I. An unusual parotid tumor with histogenetic implications for salivary gland neoplasms. Oral Surg Oral Med Oral Pathol 1983;55:374-81.  Back to cited text no. 48
49.Ortiz-Hidalgo C, de León-Bojorge B, Fernandez-Sobrino G, Sánchez Marle JF, Martin del Campo N. Sialoblastoma: Report of a congenital case with dysembroyogenic alterations of adjacent parotid gland. Histopathology2001;38:79-80.  Back to cited text no. 49
50.Krolls SO, Trodahl JN, Boyers RC. Salivary gland lesions in children. A survey of 430 cases. Cancer 1972;30:459-69.  Back to cited text no. 50


  [Table 1], [Table 2]

This article has been cited by
1 Pearls, Pitfalls, and Mimics in Pediatric Head and Neck Imaging
Felice D’Arco, Lorenzo Ugga
Neuroimaging Clinics of North America. 2022; 32(2): 433
[Pubmed] | [DOI]
2 The Cellular and Molecular Landscape of Synchronous Pediatric Sialoblastoma and Hepatoblastoma
Ran Yang, Yong Zhan, Yi Li, Shu-Yang Dai, Shi-Wei He, Chun-Jing Ye, Ling-Du Meng, De-Qian Chen, Chen-Bin Dong, Lian Chen, Gong Chen, Kui-Ran Dong, Kai Li, Shan Zheng, Jun Li, Wei Yao, Rui Dong
Frontiers in Oncology. 2022; 12
[Pubmed] | [DOI]
3 Sialoblastoma and Hepatoblastoma in an Infant: A Case Report and Review of the Literature
Lin Xu, Yumin Zhong
Iranian Journal of Radiology. 2021; 18(4)
[Pubmed] | [DOI]
4 Two Synchronous Neonatal Tumors: An Extremely Rare Case
M. Rodríguez-Zubieta,K. Albarenque,C. Lagues,A. San Roman,M. Varela,D. Russo,G. Podesta,D. Steinberg,C. Schauvinhold,A. Etchegaray,M. T. G. de Dávila,Atif A. Ahmed
Case Reports in Pathology. 2021; 2021: 1
[Pubmed] | [DOI]
5 Sialoblastoma of the submandibular gland: a distinct entity?
Riccardo Di Micco,Friederike Prüfer,Elisabeth Bruder,Alexandra Schifferli,Nicolas Gürtler
European Journal of Pediatrics. 2019; 178(8): 1301
[Pubmed] | [DOI]
6 Progressive Metastatic Sialoblastoma in a Young Child: Challenges in Treatment
Shashi Ranjani,Intezar Mehdi,Vishal Rao
Indian Journal of Medical and Paediatric Oncology. 2019; 40(02): 314
[Pubmed] | [DOI]
7 Sialoblastoma of the parotid gland in a 13-year-old girl with multiple recurrences and long-term follow-up
Panagiotis Saravakos,Joerg Hartwein,Afshin Fayyazi,Peter Andersen
Head & Neck. 2016; 38(1): E13
[Pubmed] | [DOI]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
    Article Tables

 Article Access Statistics
    PDF Downloaded541    
    Comments [Add]    
    Cited by others 7    

Recommend this journal